丁希丽 助理教授
医学科学与工程学院
北京市生物医学工程高精尖创新中心
电子邮箱：xiliding@buaa.edu.cn
【教育背景】
2014. 9-2019.6 威廉希尔 | 生物医学工程 | 博士学位
2017.10-2019.4加州大学洛杉矶分校 | 生物工程 | 联培博士
【工作经历】
2021.5-至今 威廉希尔 | 医学科学与工程学院 | 助理教授
2019.6 -2021.4威廉希尔 | 机械工程及自动化学院 | 博士后
【研究领域】
1. 小口径人工血管的研究
2. 血管材料的结构设计、免疫及降解调控研究
3. 血管内膜增生机理研究
【代表性科研项目】
1. 国家自然科学基金青年项目，32000968，基于单细胞RNA测序探讨巨噬细胞在血管再生中的作用及其机制，2021/01-2023/12，在研，主持
2. 威廉希尔青年拔尖人才支持计划，YWF-21-BJ-J-1167，巨噬细胞表型差异对血管再生的影响研究，2021/03-2021/12, 在研，主持
【代表性论著】
发表文章列表：
1. Soto J, Ding XL, Wang A, Li S. Neural crest-like stem cells for tissue regeneration. Stem Cells Translational Medicine. 2021, 10(5): 681-693.
2. Qiu X, Lee BL-P, Wong SY, Ding XL, Xu K, Zhao W, Wang D, Sochol R, Dong N, Li S. Cellular remodeling of fibrotic conduit as vascular graft.
Biomaterials. 2021, 268:120565.
3. Ding XL#, Huang Y#, Li XM, Liu ST, Tian F, Niu XF, Chu ZW, Chen DS, Liu HF, Fan YB. Three-dimensional silk fibroin scaffolds incorporated with graphene for bone regeneration. Journal of Biomedical Materials Research Part A,
2021, 109(4): 515-523.
4. Tian BX, Ding XL, Song Y, Chen WC, Liang JQ, Yang L, Fan YB, Li S, Zhou Y. Matrix stiffness regulates SMC functions via TGF-beta signaling pathway. Biomaterials, 2019, 221: 119497.
5. Guo JC, Liu XY, Ding XL, Wang LZ, Fan YB. Biomechanical and mechanical behavior of the plantar fascia in macro and micro structures.
Journal of biomechanics, 2018, 76: 160-166.
6. Yang Y#, Ding XL#, Zou TQ, Peng G, Liu HF, Fan YB. Preparation and characterization of electrospun graphene/silk fibroin conductive
fibrous scaffolds. Rsc Advances, 2017, 7(13): 7954-7963.
7. Wang DY, Sun Y, Ding XL, Peng G, Zou TQ, Liu HF, Fan YB. Influence of micropatterned silk fibroin films on human umbilical endothelial
cell behaviors. Journal of Medical and Biological Engineering, 2017, 37(5): 750-759.
8. Liu HF, Gong XH, Jing XH, Ding XL, Yao Y, Huang Y, Fan YB. Shear stress with appropriate time-step and amplification enhances endothelial cell retention on vascular grafts. Journal of Tissue Engineering and Regenerative Medicine,
2017, 11(11): 2965-2978.
9. Li Y, Chu Z, Li X, Ding XL, Guo M, Zhao H, Yao J, Wang L, Cai Q, Fan Y. The effect of mechanical loads on the degradation of aliphatic
biodegradable polyesters. Regenerative Biomaterials, 2017, 4(3): 179-190.
10. Chu ZW, Li XM, Li Y, Zheng Q, Feng CL, Guo M, Ding XL, Feng WT, Gao YM, Yao J, Chen XF, Wang LZ, Fan YB. Effects of different
fluid shear stress patterns on the in vitro degradation of poly(lactide-co-glycolide) acid membranes. Journal of Biomedical Materials Research Part A, 2017, 105(1): 23-30.
11. Ding XL, Zou TQ, Gong XH, Ren CH, Kang HY, Xu P, Liu HF, Fan YB. Trilayered sulfated silk fibroin vascular grafts enhanced with braided
silk tube. Journal of Bioactive and Compatible Polymers, 2016, 31(6): 613-623.
12. Ding XL, Wu CQ, Ha T, Wang LZ, Huang Y, Kang HY, Zhang YY, Liu HF, Fan YB. Hydroxyapatite-containing silk fibroin nanofibrous scaffolds for tissue-engineered periosteum. Rsc Advances, 2016, 6(23): 19463-19474.
13. Yao Y, Liu HF, Ding XL, Jing XH, Gong XH, Zhou G, Fan YB. Preparation and characterization of silk fibroin/poly(l-lactide-co-epsilon-caprolactone) nanofibrous membranes for tissue engineering applications. Journal of Bioactive and Compatible Polymers, 2015, 30(6): 633-648.
14. Liu HF,, Wei X, Ding XL, Li XM, Zhou G, Li P, Fan YB. Comparison of cellular responses of mesenchymal stem cells derived from bone
marrow and synovium on combined silk scaffolds. Journal of Biomedical Materials Research Part A, 2015, 103(1): 115-125.
15. Ding XL#, Wei X#, Huang Y, Guan CD, Zou TQ, Wang S, Liu HF, Fan YB. Delivery of demineralized bone matrix powder using a salt-leached silk fibroin carrier for bone regeneration. Journal of Materials Chemistry B, 2015, 3(16): 3177-3188.
16. Ding XL, Liu HF, Fan YB. Graphene-based materials in regenerative medicine. Advanced Healthcare Materials, 2015, 4(10): 1451-1468.
17. Gong XH, Liu HF, Ding XL, Liu ML, Li XM, Zheng LS, Jia XL, Zhou G, Zou YW, Li JC, Huang XJ, Fan YB. Physiological pulsatile flow
culture conditions to generate functional endothelium on a sulfated silk fibroin nanofibrous scaffold. Biomaterials, 2014, 35(17): 4782-4791.
发明专利:
1. 刘海峰，丁希丽，毕研学，周钢，樊瑜波，一种丝素蛋白和硫酸化丝素蛋白复合管状支架的制备方法，专利号：ZL201210533518.2
2. 刘海峰，樊瑜波，丁希丽，一种丝素蛋白和脱钙骨基质复合的骨修复材料，专利号：ZL201310130923.4
3. 刘海峰，丁希丽，邹同强，樊瑜波，一种具有良好顺应性的抗凝血复合管状支架的制备方法，专利号：ZL201510030345.6
专著：
1. Haifeng Liu, Xili Ding, Yubo Fan. Vascular Grafts: Small-Diameter Tissue Engineering. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, CRC Press, Volume 11:8165-8176.
2. Yan Huang, Jing Ji, Xili Ding, Xiaoming Li. The Potential Tissues and Their Properties. Tissue Repair. Springer.
【招生】
欢迎具有材料、医学和力学等相关专业背景的优秀学子加入。有意者可直接发送简历至邮箱：xiliding@buaa.edu.cn。
